Zepbound (Tirzepatide)

Zepbound is a prescription medicine that contains tirzepatide, a dual GIP and GLP-1 receptor agonist. It mimics two natural hormones that help regulate appetite, food intake, and metabolism, slowing stomach emptying and increasing feelings of fullness.

Zepbound is FDA-approved for chronic weight management in adults with obesity, or in adults who are overweight with at least one weight-related condition, such as hypertension, dyslipidemia, type 2 diabetes, or obstructive sleep apnea. Because excess weight and insulin resistance are closely linked to MASLD and MASH, some healthcare providers prescribe Zepbound to address these underlying metabolic risk factors, even though it is not a direct liver treatment.

It is typically used as part of a broader, personalised treatment plan that may include dietary changes, physical activity, and regular monitoring by your healthcare provider, such as Liver Function Tests (LFTs) or imaging.

Zepbound activates both GIP and GLP-1 receptors. This dual action reduces appetite and food cravings, increases feelings of fullness after meals, slows how quickly food leaves the stomach, and supports healthier glucose and energy balance.

These actions target one of the central metabolic drivers behind MASLD and MASH: excess body weight. As weight decreases and metabolic regulation improves, fat tends to build up less in liver cells, and the inflammation that drives disease progression may ease.

For patients with MASLD or MASH, these metabolic changes can support treatment goals such as measurable reductions in liver fat and a lower risk of disease progression. Zepbound is not used on its own — providers pair it with dietary changes, physical activity, and regular monitoring, such as Liver Function Tests (LFTs), to support these outcomes.

Zepbound (tirzepatide) may support people with MASLD and MASH by targeting excess weight, a key metabolic risk factor that drives fat buildup and inflammation in the liver. By supporting significant, sustained weight loss and improved metabolic regulation, it may contribute to reduced liver fat and a lower risk of disease progression over time. The extent of these benefits varies from person to person, depending on their liver condition, overall metabolic health, treatment plan, and how their body responds to therapy. Zepbound is not a stand-alone liver treatment — it works best as part of a broader, personalised care plan that combines the medication with lifestyle changes, such as a liver-healthy diet and regular physical activity, along with ongoing monitoring like Liver Function Tests (LFTs) or imaging.

As with any medication, Zepbound may cause side effects, ranging from mild digestive symptoms to less common reactions. Your healthcare provider will assess whether Zepbound is a suitable option for you and will monitor your treatment response throughout therapy, adjusting the dose or overall care plan as needed to balance potential benefits against any risks.